Wigan Athletic manager Roberto Martinez has confirmed both Ivan Ramis and Shaun Maloney will miss out the visit of Premier League champions Manchester City.
The Latics have lost five of their last six meetings against City and it will be tough to stop the rot as the injury crisis deepens at the DW.
There are big concerns over forward Maloney’s groin strain, but Martinez is hopeful defender Ramis’ hamstring problem is not too serious.
“Shaun’s injury is worse than Ivan’s,” he told Sky Sports. “He has picked up a groin strain and, although we’ll assess him, it looks as though he’ll be out for a while.
“With Ivan’s injury, we managed to catch it just in time before it got worse. He felt a twinge in his hamstring and we’ll assess him to see how long he’ll be out for.”
Wigan, currently sitting 15th in the table, are already without key players Ben Watson, captain Gary Caldwell, loan star Ryo Miyaichi, Albert Crusat and Antolin Alcaraz.
The popular Spaniard also praise keeper Ali Al-Habsi, whose blunder almost cost his side three crucial points.
“I’m quite happy for him to make a mistake. For every mistake, there are 20 good saves. I’ll take that ratio any time,” he added.
“I wouldn’t take any other keeper to replace Ali, that’s how much we rate him. He’s the perfect keeper for us. He fits in with the way we play.
“He’s got another step to make and, once he gets there, he’s a keeper who can compete to win a title or Champions League.”